ProGenosis is a biotechnology company devoted in determination of proteins interactions. The proprietary technology platform is dedicated to develop efficient, innovative and convenient Bi-functional Hybrid Proteins (BHP) which can be used for protein domain studies.

The proprietary technology platform simplifies the complexity of the receptor-ligand interaction environment into a manageable unit that are suitable for laboratory studies. We offer the opportunity to use a convenient and functional research approach for displaying polypeptide or protein domain within an enzymatic scaffold.
ProGenosis creates Bi-functional Hybrid Proteins which associates a high turn over enzyme scaffold with a definite biological activity.

The ProGenosis' technology platform involves the insertion of polypeptide (protein, protein fragments, protein domain, oligopeptide, ...) within the native structure of an enzyme scaffold.

This new approach provides a means of displaying the exogenous polypeptide in the three-dimensional environment of a functional carrier enzyme. The exogenous polypeptide is reconstructed as a biologically active molecule.

As for as "nano to life" is concern, the preservation of protein activity and uniformity in an array is critical for accurate protein profiling. The BHP technology ensures that the printed proteins are functional and presented in a similar one-way orientation above the surface, thereby maximizing the opportunity for protein sites to interact with binding partners.

The overall main benefits of BHP are

• Biological function displayed in a protein scaffold.
• Correctly folded, soluble and fully functional protein.
• Positive screening procedure.
• Enzymatic reporting system.
• Bypass of wild-type protein production.
• Avoid the problem of toxic, insoluble, difficult to produce or unfunctional protein.
• No chemical conjugation → stability and uniformity of BHP.
• Recombinant protein → higher control of the final product.
• Reduction of the procurement cost and the losing of biological information.

Key products

	array

Customized Bi-functional Hybrid Protein used in recombinant protein production, antibody therapeutics, epitope mapping and immunogenicity determination, micro array system (i.e. BIOSENSOR) and to improve screening or vaccine development.

ProGenosis and Nano2Life

As a recent industrial member, ProGenosis wants to participate to the major events organized by N2L in order to share experiences, ideas and enter into mutually fruitful R&D in the field of Biosensor. We hope that our strong skill in proteins chemistry represents an essential contribution for the "Life side" of this leading Pan-European network of excellence in the nanobiotechnology field.